Protein Stability, Folding and Misfolding in Human PGK1 Deficiency
نویسندگان
چکیده
منابع مشابه
Protein Stability, Folding and Misfolding in Human PGK1 Deficiency
Conformational diseases are often caused by mutations, altering protein folding and stability in vivo. We review here our recent work on the effects of mutations on the human phosphoglycerate kinase 1 (hPGK1), with a particular focus on thermodynamics and kinetics of protein folding and misfolding. Expression analyses and in vitro biophysical studies indicate that disease-causing mutations enha...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2013
ISSN: 2218-273X
DOI: 10.3390/biom3041030